ABB FT-NIR online process analyzer is capable of meeting the requirements of the European Pharmacopoeia, the United States Pharmacopoeia, and the Chinese Pharmacopoeia, providing complete DQ, IQ, OQ, PQ documentation and procedures. The online analysis software FTSW100 is also fully compliant with 21 CFR Part 11. A typical application in the analysis of the following process:

The drying process, suitable for all kinds of drying towers, such as mixing drying tower, fluidized bed drying tower, filter drying tower, rotating drying tower, and also suitable for monitoring of freeze-drying tower. Real-time process monitoring can reduce drying cycle time, improve yield and save cost.

The mixing process, suitable for liquid and solid mixing uniformity monitoring. For example, the mixing process of bulk drug and excipient ensures the determination of mixing endpoint, makes the product have better consistency, and shorts the production cycle.

The reaction process is suitable for chemical reactions to synthesize APIs or intermediates, especially for liquid systems.

During crystallization and recrystallization reaction, the concentration of API in mother liquor was monitored, and the crystallization endpoint and feeding time were determined.

The fermentation process, suitable for monitoring culture medium, by-products, metabolites, biomass, etc., to determine the best time to add chemical inducers, eliminate sampling and sterility problems, shorten the production cycle